A simple and inexpensive eye test could one day aid detection and diagnosis of major neurological diseases such as Alzheimer's at an earlier stage than is currently possible, according to new research by scientists at the University College London and published in Cell Death & Disease. Professors Francesca Cordeiro and Stephen Moss demonstrated a new technique that enables retinal, and therefore brain cell death, to be directly measured in real time. The method could not only refine diagnosis of neurodegenerative disorders and help track disease progress, but also aid the assessment and development of new treatments. The technique uses fluorescent markers that attach themselves to the relevant cells and indicate the stage of cell death. The retina is then observed using a customized laser ophthalmoscope. Until now, this kind of technique has only been used in cells in the lab. This new research, demonstrated on animal models, is the first in vivo demonstration of retinal nerve cell death in Alzheimer's. Said Professor Cordeiro of the UCL Institute of Ophthalmology, "The death of nerve cells is the key event in all neurodegenerative disorders, but until now it has not been possible to study cell death in real time. This technique means we should be able to directly observe retinal nerve cell death in patients, which has a number of advantages in terms of effective diagnosis. This could be critically important since identification of the early stages could lead to successful reversal of the disease progression with treatment. Currently, the biggest obstacle to research into new treatments for neurodegenerative diseases is the lack of a technique where the brain's response to new treatments can be directly assessed. This technique could potentially help overcome that." Professor Cordeiro's team is further along with work using the same technique to detect and assess glaucoma and will be conducting their first patient trials later this year. "The equipment used for this research was customized to suit animal models, but is essentially the same as is used in hospitals and clinics worldwide. It is also inexpensive and non-invasive, which makes us fairly confident that we can progress quickly to its use in patients. Few people realize that the retina is a direct, albeit thin, extension of the brain. It is entirely possible that in the future a visit to check on your eyesight will also be a check on the state of your brain," Cordeiro added.
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